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Article

Discovering metabolite quantitative trait loci in asthma using an isolated population.

The Journal of allergy and clinical immunology - 1 May 2022

Johnson Randi K, Brunetti Tonya, Quinn Kevin, Doenges Katrina, Campbell Monica, Arehart Christopher, Taub Margaret A, Mathias Rasika A, Reisdorph Nichole, Barnes Kathleen C, Daya Michelle

Abstract excerpt

BACKGROUND: Integration of metabolomics with genetics may advance understanding of disease pathogenesis but has been underused in asthma genetic studies. OBJECTIVE: We sought to discover new genetic effects in asthma and to characterize the molecular consequences of asthma genetic risk through integration with the metabolome in a homogeneous population. METHODS: From fasting serum samples collected on 348 Tangier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34780848
DOI: 10.1016/j.jaci.2021.11.002
PMCID: PMC9081120

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