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Total Biosynthesis of the Tubulin-Binding Alkaloid Colchicine

15 Nov 2021

Abstract excerpt

Colchicine ( 1 ) is a bioactive plant alkaloid from Colchicum and Gloriosa species that is used as a pharmaceutical treatment for inflammatory diseases, including gouty arthritis and familial Mediterranean fever. The activity of this alkaloid is attributed to its ability to bind tubulin dimers and inhibit microtubule assembly, which not only promotes anti-inflammatory effects, but also makes colchicine a potent...

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PMID: 34780686
DOI: 10.1021/jacs.1c08659

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