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A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes

2023-05-12

Abstract excerpt

Numerous eukaryotic toxins that accumulate in geophytic plants are valuable in the clinic, yet their biosynthetic pathways have remained elusive. A lead example is the >150 Amaryllidaceae alkaloids (AmAs) including galantamine, an FDA-approved treatment for Alzheimer’s disease. We show that while AmAs accumulate to high levels in many tissues in daffodils, biosynthesis is localized to nascent, growing tissue at th...

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Literature Corpus work
3caccd7e-e03d-569d-9bf4-046530f26ba4
DOI
10.1101/2023.05.12.540595
Open publication

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A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytesDOI 10.1101/2023.05.12.540595
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