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Article

Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape.

eLife - 15 Nov 2021

Aponte Jose D, Katz David C, Roth Daniela M, Vidal-García Marta, Liu Wei, Andrade Fernando, Roseman Charles C, Murray Steven A, Cheverud James, Graf Daniel, Marcucio Ralph S, Hallgrímsson Benedikt

Abstract excerpt

Realistic mappings of genes to morphology are inherently multivariate on both sides of the equation. The importance of coordinated gene effects on morphological phenotypes is clear from the intertwining of gene actions in signaling pathways, gene regulatory networks, and developmental processes underlying the development of shape and size. Yet, current approaches tend to focus on identifying and localizing the...

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PMID: 34779766
DOI: 10.7554/eLife.68623
PMCID: PMC8631940

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