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Article

Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

10 Nov 2021

Abstract excerpt

BACKGROUND: A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated. Studies on the interferon-γ (IFN-γ)/ Janus kinase (JAK)/ signal transducer and activator of transcription (STAT)1 pathway provide new directions in this regard. METHODS: Our study applies three colon cancer cell lines, including...

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PMID: 34758826
DOI: 10.1186/s12929-021-00769-9

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