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Article

SH3BP2 mutations potentiate osteoclastogenesis via PLCγ.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 2010

Lietman Steven A, Yin Lihong, Levine Michael A

Abstract excerpt

To determine the mechanism for the increased osteoclastogenesis in the jaw of cherubism patients with SH3BP2 mutations we evaluated the effect of mutant compared to wild-type SH3BP2 on activation of osteoclast signaling pathways. Indeed mutant forms of SH3BP2 do induce greater osteoclastogenesis. Heterozygous activating mutations in exon 9 of SH3BP2 have been found in most patients with cherubism, an unusual...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NFATC Transcription Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 20872577
DOI: 10.1002/jor.21164
PMCID: PMC2948751

Genes

SH3BP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SH3BP2 mutations potentiate osteoclastogenesis via PLCγ.PMID 20872577Read ↗

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