Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jawing about TNF: new hope for cherubism.

Cell - 12 Jan 2007

Novack Deborah Veis, Faccio Roberta

Abstract excerpt

Mutations in the SH3-domain binding protein 2 (SH3BP2) are known to cause a rare childhood disorder called cherubism that is characterized by inflammation and bone loss in the jaw, but the mechanism has remained unclear. In this issue, Ueki et al. (Ueki et al., 2007) now demonstrate that a cherubism mutation activates mouse Sh3bp2 resulting in enhanced production of the cytokine TNF-alpha by myeloid cells,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Bone Resorption
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Macrophage Colony-Stimulating Factor

Share to Osteoclasts

Share to RANK Ligand

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 17218248
DOI: 10.1016/j.cell.2006.12.019

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jawing about TNF: new hope for cherubism.PMID 17218248Read ↗

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.Semantic proximity Read ↗

Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of CherubismSemantic proximity Read ↗

[Molecular and Cellular Pathogenesis of Cherubism].Semantic proximity Read ↗

Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.Semantic proximity Read ↗

Identification of a novel mutation of SH3BP2 in cherubism and demonstration that SH3BP2 mutations lead to increased NFAT activation.Semantic proximity Read ↗

Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model.Semantic proximity Read ↗

Exploring a cherubism bone phenotype outside the craniofacial region.Semantic proximity Read ↗

SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model.Semantic proximity Read ↗

A novel mutation in the SH3BP2 gene causes cherubism: case reportSemantic proximity Read ↗

SH3BP2 mutations potentiate osteoclastogenesis via PLCγ.Semantic proximity Read ↗

Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling.Semantic proximity Read ↗

Point mutations of 3BP2 identified in human‐inherited disease cherubism result in the loss of functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.