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Article

Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment.

Basic & clinical pharmacology & toxicology - 1 Jan 2022

Yamoune Sabrina, Wintz Katharina, Niederau Christian, Craveiro Rogerio B, Wolf Michael, Stingl Julia

Abstract excerpt

In genome-wide association studies, the CYP2C8 gene locus has been reported to be associated with bisphosphonate-related osteonecrosis of the jaw, a severe devastating side effect of antiresorptive bone treatment. The aim of this study was to elucidate the putative pathomechanism explaining the association between the genetic polymorphism with the alleles CYP2C8*2 and *3 causing low CYP2C8 activity, and disturbed...

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Identifiers

PMID: 34740282
DOI: 10.1111/bcpt.13681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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