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Assessment of the relationships between genetic determinants of thyroid functions and bipolar disorder: A mendelian randomization study.

Journal of affective disorders - 1 Feb 2022

Chen Guoqing, Lv Honggang, Zhang Xiao, Gao Yan, Liu Xia, Gu Chuanzheng, Xue Ranran, Wang Qiuling, Chen Min, Zhai Jinguo, Yue Weihua, Yu Hao

Abstract excerpt

BACKGROUND: Thyroid functions (TFs) have been implicated in the initiation and propagation of psychiatric disorders. Observational studies have shown associations of TFs with psychiatric disorders. However, the relationship between TFs and psychiatric diseases were still unclear. METHODS: Genetic instruments for 6 TF-realted indexes, including free thyroxine (FT4), triiodothyronine (FT3):FT4 ratio, thyrotropin...

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Bipolar Disorder
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34728293
DOI: 10.1016/j.jad.2021.10.101

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