Article
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 May 2014
Durk Matthew R, Han Kyung, Chow Edwin C Y, Ahrens Rosemary, Henderson Jeffrey T, Fraser Paul E, Pang K Sandy
Abstract excerpt
We demonstrate a role of the vitamin D receptor (VDR) in reducing cerebral soluble and insoluble amyloid-β (Aβ) peptides. Short-term treatment of two human amyloid precursor protein-expressing models, Tg2576 and TgCRND8 mice, with 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the endogenous active ligand of VDR, resulted in higher brain P-glycoprotein (P-gp) and lower soluble Aβ levels, effects negated with...
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