The correlation of substitution effects across populations and generations in the presence of nonadditive functional gene action.

doi:10.1093/genetics/iyab138

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Article

The correlation of substitution effects across populations and generations in the presence of nonadditive functional gene action.

Genetics - 10 Dec 2021

Legarra Andres, Garcia-Baccino Carolina A, Wientjes Yvonne C J, Vitezica Zulma G

Abstract excerpt

Allele substitution effects at quantitative trait loci (QTL) are part of the basis of quantitative genetics theory and applications such as association analysis and genomic prediction. In the presence of nonadditive functional gene action, substitution effects are not constant across populations. We develop an original approach to model the difference in substitution effects across populations as a first order...

Topics

Alleles
Animals
Computer Simulation
Gene Frequency
Genes
Genetic Variation
Genetics, Population
Genotype
Humans
Models, Genetic
Models, Statistical
Mutagenesis

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Identifiers

PMID: 34718531
DOI: 10.1093/genetics/iyab138
PMCID: PMC8664574

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