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Article

SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection

29 Oct 2021

Abstract excerpt

= 1) following experimental exposure. Five nonsynonymous changes relative to the USA-WA1/2020 prototype strain were near fixation in the stock used for inoculation but had reverted to wild-type sequences at these sites in dogs, cats, and hamsters within 1- to 3-d postexposure. A total of 14 emergent variants (six in nonstructural genes, six in spike, and one each in orf8 and nucleocapsid) were detected in viruses...

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PMID: 34716263
DOI: 10.1073/pnas.2105253118

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