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Article

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.

PLoS pathogens - 1 Feb 2021

Braun Katarina M, Moreno Gage K, Halfmann Peter J, Hodcroft Emma B, Baker David A, Boehm Emma C, Weiler Andrea M, Haj Amelia K, Hatta Masato, Chiba Shiho, Maemura Tadashi, Kawaoka Yoshihiro, Koelle Katia, O'Connor David H, Friedrich Thomas C

Abstract excerpt

The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, undergo antigenic evolution depend on the ways genetic variation is generated and selected within and between individual hosts. Using domestic cats as a model, we show that SARS-CoV-2 consensus sequences remain largely unchanged over time within hosts, while dynamic sub-consensus diversity reveals processes of...

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Identifiers

PMID: 33635912
DOI: 10.1371/journal.ppat.1009373
PMCID: PMC7946358

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