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Article

Drug-induced premature senescence model in human dental follicle stem cells.

Oncotarget - 31 Jan 2017

Zhai Yuanfen, Wei Rongbin, Liu Junjun, Wang Huihui, Cai Wenping, Zhao Mengmeng, Hu Yongguang, Wang Shuwei, Yang Tianshu, Liu Xiaodong, Yang Jianhua, Liu Shangfeng

Abstract excerpt

Aging is identified by a progressive decline of physiological integrity leading to age-related degenerative diseases, but its causes is unclear. Human dental pulp stem cells (hDPSCs) has a remarkable rejuvenated capacity that relies on its resident stem cells. However, because of the lack of proper senescence models, exploration of the underlying molecular mechanisms has been hindered. Here, we established a...

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PMID: 28030852
DOI: 10.18632/oncotarget.14085
PMCID: PMC5352320

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