Article
Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome of Dictyostelium discoideum.
G3 (Bethesda, Md.) - 2 Sept 2020
Kucukyildirim Sibel, Behringer Megan, Sung Way, Brock Debra A, Doak Thomas G, Mergen Hatice, Queller David C, Strassmann Joan E, Lynch Michael
Abstract excerpt
We describe the rate and spectrum of spontaneous mutations for the social amoeba Dictyostelium discoideum, a key model organism in molecular, cellular, evolutionary and developmental biology. Whole-genome sequencing of 37 mutation accumulation lines of D. discoideum after an average of 1,500 cell divisions yields a base-substitution mutation rate of 2.47 × 10-11 per site per generation, substantially lower than...
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