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Quadruplexes in 'Dicty': crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome.

Nucleic acids research - 1 Jun 2018

Guédin Aurore, Lin Linda Yingqi, Armane Samir, Lacroix Laurent, Mergny Jean-Louis, Thore Stéphane, Yatsunyk Liliya A

Abstract excerpt

Guanine-rich DNA has the potential to fold into non-canonical G-quadruplex (G4) structures. Analysis of the genome of the social amoeba Dictyostelium discoideum indicates a low number of sequences with G4-forming potential (249-1055). Therefore, D. discoideum is a perfect model organism to investigate the relationship between the presence of G4s and their biological functions. As a first step in this...

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PMID: 29718337
DOI: 10.1093/nar/gky290
PMCID: PMC6007418

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Source receipt: pubmed, retrieved 7 Sept 2026.

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