Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA

20 Oct 2021

Abstract excerpt

mRNA is a blooming technology for vaccination and has gained global attention during the SARS-CoV-2 pandemic. However, the recent clinical trials have highlighted increased reactogenicity when using high mRNA doses. Intending to increase the potency of mRNA therapeutics and to decrease the therapeutic dose, we designed a mRNA backbone and optimized the mRNA purification process. We used the enhanced green...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34692232
DOI: 10.1016/j.omtn.2021.10.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNAPMID 34692232Read ↗

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinicsSemantic proximity Read ↗

Technological breakthroughs and advancements in the application of mRNA vaccines: a comprehensive exploration and future prospectsSemantic proximity Read ↗

mRNA vaccine sequence and structure design and optimization: Advances and challengesSemantic proximity Read ↗

The Development of mRNA Vaccines for Infectious Diseases: Recent UpdatesSemantic proximity Read ↗

Development of mRNA Vaccines/Therapeutics and Their Delivery SystemSemantic proximity Read ↗

An Update on mRNA-Based Viral VaccinesSemantic proximity Read ↗

Current Developments and Challenges of mRNA VaccinesSemantic proximity Read ↗

mRNA vaccines for infectious diseases: principles, delivery and clinical translationSemantic proximity Read ↗

mRNA vaccines in the prevention and treatment of diseasesSemantic proximity Read ↗

mRNA-based modalities for infectious disease managementSemantic proximity Read ↗

From COVID-19 to Global Health: Challenges and Opportunities in mRNA Vaccine ProductionSemantic proximity Read ↗

mRNA vaccines: the most recent clinical applications of synthetic mRNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.