Article

Empowering rare variant burden-based gene-trait association studies via optimized computational predictor choice

2021-09-20

Abstract excerpt

<h4>Background</h4> Causal gene/trait relationships can be identified via observation of an excess (or reduced) burden of rare variation in a given gene within humans who have that trait. Although computational predictors can improve the power of such ‘burden’ tests, it is unclear which are optimal for this task. <h4>Method</h4> Using 140 gene-trait combinations with a reported rare-variant burden association, w...

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Literature Corpus work: 7aefde0b-dfc2-5e59-a66e-270569d0f3dd
DOI: 10.1101/2021.09.20.459182

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