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Article

ERa-36 instead of ERa mediates the stimulatory effects of estrogen on the expression of viral oncogenes HPV E6/E7 and the malignant phenotypes in cervical cancer cells.

Virus research - 1 Dec 2021

Zhang Xiao, Zhang Aowei, Zhang Xi, Hu Shiyue, Bao Zhenghao, Zhang Yuhao, Jiang Xiaoyan, He Hongpeng, Zhang Tong-Cun

Abstract excerpt

High risk human papillomavirus (HPV) is the main causative factor of cervical cancer. In addition, estrogen and its receptors are also involved in the development of carcinogenesis. The canonical estrogen receptor ERα is frequently deficient while its variant ERα-36 is highly expressed in cervical cancer cells. The biological significance for this receptor transition from ERα to ERα-36 remains unclear. In the...

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Identifiers

PMID: 34662680
DOI: 10.1016/j.virusres.2021.198602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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