Article
The role of T-cells in neurobehavioural development: Insights from the immunodeficient nude mice.
Behavioural brain research - 10 Feb 2022
Bauer-Negrini Guilherme, Deckmann Iohanna, Schwingel Gustavo Brum, Hirsch Mauro Mozael, Fontes-Dutra Mellanie, Carello-Collar Giovanna, Halliwell Diane E, Paraskevaidi Maria, Morais Camilo L M, Martin Francis L, Riesgo Rudimar, Gottfried Carmem, Bambini-Junior Victorio
Abstract excerpt
Mice homozygous for the nude mutation (Foxn1nu) are hairless and exhibit congenital dysgenesis of the thymic epithelium, resulting in a primary immunodeficiency of mature T-cells, and have been used for decades in research with tumour grafts. Early studies have already demonstrated social behaviour impairments and central nervous system (CNS) alterations in these animals, but did not address the complex interplay...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.