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Article

Somatic mosaics in hereditary tumor predisposition syndromes.

European journal of medical genetics - 1 Dec 2021

Steinke-Lange Verena, de Putter Robin, Holinski-Feder Elke, Claes Kathleen Bm

Abstract excerpt

Historically, it is estimated that 5-10% of cancer patients carry a causative genetic variant for a tumor predisposition syndrome. These conditions have high clinical relevance as they are actionable regarding risk-specific surveillance, predictive genetic testing, reproductive options, and - in some cases - risk reducing surgery or targeted therapy. Every individual is born with on average 0.5-1 exonic mosaic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34655802
DOI: 10.1016/j.ejmg.2021.104360

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