Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola.

doi:10.1186/s12879-021-06763-8

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Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola.

BMC infectious diseases - 12 Oct 2021

Rando-Segura Ariadna, Aznar María Luisa, Moreno María Milagros, Espasa Soley Mateu, Sulleiro Igual Elena, Bocanegra Garcia Cristina, Gil Olivas Eva, Nindia Eugénio Arlete, Escartin Huesca Carlos, Zacarias Adriano, Vegue Collado Josep, Katimba Domingos, Vivas Cano Maria Carmen, Gabriel Estevao, López García Maria Teresa, Pumarola Suñe Tomas, Molina Romero Israel, Tórtola Fernández María Teresa

Abstract excerpt

BACKGROUND: The importance of Mycobacterium tuberculosis strains with disputed rpoB mutations remains to be defined. This study aimed to assess the frequency and types of rpoB mutations in M. tuberculosis isolates from Cubal, Angola, a country with a high incidence of tuberculosis. METHODS: All isolates included (n = 308) were analyzed using phenotypic drug susceptibility testing and GenoType MTBDRplus assay. DNA...

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PMID: 34641802
DOI: 10.1186/s12879-021-06763-8
PMCID: PMC8507306

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