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Article

The prevalence and distribution of the amyloidogenic transthyretin ( <i> <scp>TTR</scp> </i> ) V122I allele in Africa

14 Jul 2016

Abstract excerpt

BACKGROUND: Transthyretin (TTR) pV142I (rs76992529-A) is one of the 113 variants in the human TTR gene associated with systemic amyloidosis. It results from a G to A transition at a CG dinucleotide in the codon for amino acid 122 of the mature protein (TTR V122I). The allele frequency is 0.0173 in African Americans. METHODS: PCR-based assays to genotype 2767 DNA samples obtained from participants in genetic...

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PMID: 27652282
DOI: 10.1002/mgg3.231

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The prevalence and distribution of the amyloidogenic transthyretin ( <i> <scp>TTR</scp> </i> ) V122I allele in AfricaPMID 27652282Read ↗

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