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Article

Duck MDA5 functions in innate immunity against H5N1 highly pathogenic avian influenza virus infections

18 Jun 2014

Abstract excerpt

Melanoma differentiation-associated gene 5 (MDA5) is an important intracellular receptor that recognizes long molecules of viral double-stranded RNA in innate immunity. To understand the mechanism of duck MDA5-mediated innate immunity, we cloned the MDA5 cDNA from the Muscovy duck (Cairina moschata). Quantitative real-time PCR analysis indicates that duck MDA5 mRNA was constitutively expressed in all sampled...

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PMID: 24939427
DOI: 10.1186/1297-9716-45-66

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