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Article

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling.

British journal of cancer - 1 Nov 2021

Hamis Sara J, Kapelyukh Yury, McLaren Aileen, Henderson Colin J, Roland Wolf C, Chaplain Mark A J

Abstract excerpt

BACKGROUND: Simultaneous inhibition of multiple components of the BRAF-MEK-ERK cascade (vertical inhibition) has become a standard of care for treating BRAF-mutant melanoma. However, the molecular mechanism of how vertical inhibition synergistically suppresses intracellular ERK activity, and consequently cell proliferation, are yet to be fully elucidated. METHODS: We develop a mechanistic mathematical model that...

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Identifiers

PMID: 34621046
DOI: 10.1038/s41416-021-01565-w
PMCID: PMC8608797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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