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Article

Real-time quantification of the transmission advantage associated with a single mutation in pathogen genomes: a case study on the D614G substitution of SARS-CoV-2.

BMC infectious diseases - 7 Oct 2021

Zhao Shi, Lou Jingzhi, Cao Lirong, Zheng Hong, Chong Marc K C, Chen Zigui, Chan Renee W Y, Zee Benny C Y, Chan Paul K S, Wang Maggie H

Abstract excerpt

BACKGROUND: The COVID-19 pandemic poses serious threats to global health, and the emerging mutation in SARS-CoV-2 genomes, e.g., the D614G substitution, is one of the major challenges of disease control. Characterizing the role of the mutation activities is of importance to understand how the evolution of pathogen shapes the epidemiological outcomes at population scale. METHODS: We developed a statistical...

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Identifiers

PMID: 34620109
DOI: 10.1186/s12879-021-06729-w
PMCID: PMC8495436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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