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Article

Kidney damage causally affects the brain cortical structure: A Mendelian randomization study.

EBioMedicine - 1 Oct 2021

Chen Xiong, Kong Jianqiu, Pan Jiexin, Huang Kai, Zhou Wenhao, Diao Xiayao, Cai Jiahao, Zheng Junjiong, Yang Xuefan, Xie Weibin, Yu Hao, Li Jiande, Pei Lu, Dong Wen, Qin Haide, Huang Jian, Lin Tianxin

Abstract excerpt

BACKGROUND: Alterations in the brain cortical structures of patients with chronic kidney disease (CKD) have been reported; however, the cause has not been determined yet. Herein, we used Mendelian randomization (MR) to reveal the causal effect of kidney damage on brain cortical structure. METHODS: Genome-wide association studies summary data of estimated glomerular filtration rate (eGFR) in 480,698 participants...

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Identifiers

PMID: 34619639
DOI: 10.1016/j.ebiom.2021.103592
PMCID: PMC8498227

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