Article
Fetal Estrogens are not Involved in Sex Determination But Critical for Early Ovarian Differentiation in Rabbits.
Endocrinology - 1 Jan 2022
Jolivet Geneviève, Daniel-Carlier Nathalie, Harscoët Erwana, Airaud Eloïse, Dewaele Aurélie, Pierson Cloé, Giton Frank, Boulanger Laurent, Daniel Nathalie, Mandon-Pépin Béatrice, Pannetier Maëlle, Pailhoux Eric
Abstract excerpt
AROMATASE is encoded by the CYP19A1 gene and is the cytochrome enzyme responsible for estrogen synthesis in vertebrates. In most mammals, a peak of CYP19A1 gene expression occurs in the fetal XX gonad when sexual differentiation is initiated. To elucidate the role of this peak, we produced 3 lines of TALEN genetically edited CYP19A1 knockout (KO) rabbits that were devoid of any estradiol production. All the KO XX...
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