Article
Association of Nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study.
Heart and vessels - 1 Apr 2022
Otaki Yoichiro, Watanabe Tetsu, Sato Junya, Kobayashi Yuta, Aono Tomonori, Saito Yuji, Goto Jun, Takahashi Hiroki, Arimoto Takanori, Sato Hidenori, Konta Tsuneo, Ueno Yoshiyuki, Watanabe Masafumi
Abstract excerpt
BACKGROUND: Nephronophthisis (NPHP) 4 gene encoding nephrocystin-4, which contributes to end-stage renal disease in children and young adults, is involved in the development of the heart and kidneys. Cardiorenal syndrome (CRS), which consists of bidirectional dysfunction of the heart and kidneys, is a risk factor for cardiovascular events. Single-nucleotide polymorphisms (SNPs) within the NPHP4 gene are...
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