Article
A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
PLoS genetics - 1 Jan 2012
Urabe Yuji, Tanikawa Chizu, Takahashi Atsushi, Okada Yukinori, Morizono Takashi, Tsunoda Tatsuhiko, Kamatani Naoyuki, Kohri Kenjiro, Chayama Kazuaki, Kubo Michiaki, Nakamura Yusuke, Matsuda Koichi
Abstract excerpt
Nephrolithiasis is a common nephrologic disorder with complex etiology. To identify the genetic factor(s) for nephrolithiasis, we conducted a three-stage genome-wide association study (GWAS) using a total of 5,892 nephrolithiasis cases and 17,809 controls of Japanese origin. Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19),...
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