Phospholamban immunostaining is a highly sensitive and specific method for diagnosing phospholamban p.Arg14del cardiomyopathy.

doi:10.1016/j.carpath.2017.05.004

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Article

Phospholamban immunostaining is a highly sensitive and specific method for diagnosing phospholamban p.Arg14del cardiomyopathy.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Te Rijdt Wouter P, van der Klooster Z Joy, Hoorntje Edgar T, Jongbloed Jan D H, van der Zwaag Paul A, Asselbergs Folkert W, Dooijes Dennis, de Boer Rudolf A, van Tintelen J Peter, van den Berg Maarten P, Vink Aryan, Suurmeijer Albert J H

Abstract excerpt

Phospholamban (PLN) p.Arg14del cardiomyopathy is associated with an increased risk of malignant ventricular arrhythmias and severe heart failure and a poor prognosis from late adolescence. It can be diagnosed in whole heart specimens, but rarely in right ventricular biopsy specimens, by PLN immunohistochemistry showing PLN-containing aggregates concentrated in cardiomyocytes in dense perinuclear aggresomes. The...

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Share to Arrhythmogenic Right Ventricular Dysplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28759816
DOI: 10.1016/j.carpath.2017.05.004

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