Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of Enteric Neural Stem Cell Niche and Enteric Nervous System Development in Hirschsprung Disease.

International journal of molecular sciences - 7 Sept 2021

Ji Yue, Tam Paul Kwong-Hang, Tang Clara Sze-Man

Abstract excerpt

The development of the enteric nervous system (ENS) is highly modulated by the synchronized interaction between the enteric neural crest cells (ENCCs) and the neural stem cell niche comprising the gut microenvironment. Genetic defects dysregulating the cellular behaviour(s) of the ENCCs result in incomplete innervation and hence ENS dysfunction. Hirschsprung disease (HSCR) is a rare complex neurocristopathy in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enteric Nervous System
Share to Glial Cell Line-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hirschsprung Disease

Share to Neural Crest

Share to Neural Stem Cells

Share to Receptor, Endothelin B

Share to Regenerative Medicine

Share to Stem Cell Niche

Source

Open in PubMed Open full text

Identifiers

PMID: 34575824
DOI: 10.3390/ijms22189659
PMCID: PMC8465795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of Enteric Neural Stem Cell Niche and Enteric Nervous System Development in Hirschsprung Disease.PMID 34575824Read ↗

Building a brain in the gut: development of the enteric nervous systemSemantic proximity Read ↗

“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a reviewSemantic proximity Read ↗

Enteric nervous system development: migration, differentiation, and diseaseSemantic proximity Read ↗

Development of the enteric nervous system: bringing together cells, signals and genesSemantic proximity Read ↗

The developmental etiology and pathogenesis of Hirschsprung disease.Semantic proximity Read ↗

Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new playersSemantic proximity Read ↗

Literature review: enteric nervous system development, genetic and epigenetic regulation in the etiology of Hirschsprung's diseaseSemantic proximity Read ↗

Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studiesSemantic proximity Read ↗

Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studiesSemantic proximity Read ↗

Hirschsprung disease: a developmental disorder of the enteric nervous systemSemantic proximity Read ↗

From diversity to disease: unravelling the role of enteric glial cellsSemantic proximity Read ↗

Enteric mesenchymal cells support the growth of postnatal enteric neural stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.