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Article

A Common CDH13 Variant Is Associated with Low Agreeableness and Neural Responses to Working Memory Tasks in ADHD.

Genes - 29 Aug 2021

Ziegler Georg C, Ehlis Ann-Christine, Weber Heike, Vitale Maria Rosaria, Zöller Johanna E M, Ku Hsing-Ping, Schiele Miriam A, Kürbitz Laura I, Romanos Marcel, Pauli Paul, Kalisch Raffael, Zwanzger Peter, Domschke Katharina, Fallgatter Andreas J, Reif Andreas, Lesch Klaus-Peter

Abstract excerpt

The cell-cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions....

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Identifiers

PMID: 34573337
DOI: 10.3390/genes12091356
PMCID: PMC8471784

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