Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location-dependent patterns of genetic and epigenetic alterations.

doi:10.1002/path.5808

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Article

Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location-dependent patterns of genetic and epigenetic alterations.

The Journal of pathology - 1 Jan 2022

Jurmeister Philipp, Wrede Niklas, Hoffmann Inga, Vollbrecht Claudia, Heim Daniel, Hummel Michael, Wolkenstein Peggy, Koch Ines, Heynol Verena, Schmitt Wolfgang Daniel, Thieme Anne, Teichmann Daniel, Sers Christine, von Deimling Andreas, Thierauf Julia Cara, von Laffert Maximilian, Klauschen Frederick, Capper David

Abstract excerpt

Cutaneous, ocular, and mucosal melanomas are histologically indistinguishable tumors that are driven by a different spectrum of genetic alterations. With current methods, identification of the site of origin of a melanoma metastasis is challenging. DNA methylation profiling has shown promise for the identification of the site of tumor origin in various settings. Here we explore the DNA methylation landscape of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34564861
DOI: 10.1002/path.5808

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