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Article

Genetic differences between Japan and other countries in cyp51A polymorphisms of Aspergillus fumigatus.

Mycoses - 1 Nov 2021

Majima Hidetaka, Arai Teppei, Kusuya Yoko, Takahashi Hiroki, Watanabe Akira, Miyazaki Yasunari, Kamei Katsuhiko

Abstract excerpt

BACKGROUND: Mutations in cyp51A gene are known as main mechanisms of azole resistance in Aspergillus fumigatus, whereas azole-susceptible strains also carry cyp51A mutations (polymorphisms). The polymorphisms found in Europe mainly consist of two combinations of mutations, that is combinations of five single-nucleotide polymorphisms (SNPs) of cyp51A, referred to as cyp51A-5SNPs, and combinations of three SNPs of...

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PMID: 34558115
DOI: 10.1111/myc.13370

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