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Article

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins.

Cell reports - 21 Sept 2021

Bosso Matteo, Stürzel Christina M, Kmiec Dorota, Badarinarayan Smitha Srinivasachar, Braun Elisabeth, Ito Jumpei, Sato Kei, Hahn Beatrice H, Sparrer Konstantin M J, Sauter Daniel, Kirchhoff Frank

Abstract excerpt

Subtype C is the most prevalent clade of human immunodeficiency virus type 1 (HIV-1) worldwide. The reasons for this are poorly understood. Here, we demonstrate that a characteristic additional third nuclear factor κB (NF-κB) binding site in the long terminal repeat (LTR) promoter allows subtype C HIV-1 strains to evade restriction by nuclear PYHIN proteins, which sequester the transcription factor Sp1. Further,...

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Identifiers

PMID: 34551301
DOI: 10.1016/j.celrep.2021.109735
PMCID: PMC8505707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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