Article
Sequence insertions in the HIV type 1 subtype C viral promoter predominantly generate an additional NF-κB binding site.
AIDS research and human retroviruses - 1 Oct 2012
Bachu Mahesh, Mukthey Anil Babu, Murali Rajesh V, Cheedarla Narayanaiah, Mahadevan Anita, Shankar Susarla K, Satish Kadappa S, Kundu Tapas K, Ranga Udaykumar
Abstract excerpt
After screening a large number of clinical samples of HIV-1 subtype C in India, a subset of viral strains containing sequence insertions upstream of the viral enhancer has been identified. The sequence insertions contained binding sites for at least two different transcription factors NF-κB and RBEIII, importantly, in a mutually exclusive fashion. Furthermore, while some of the viral strains contained insertions...
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