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Phospholipase C Beta 1: a Candidate Signature Gene for Proneural Subtype High-Grade Glioma

28 Nov 2015

Abstract excerpt

Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the potential role of PLCβ1 as a biomarker in high-grade glioma (HGG). PLCβ1 expression is significantly...

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PMID: 26614510
DOI: 10.1007/s12035-015-9518-2

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