Article
ARID1A-mutated ovarian cancers depend on HDAC6 activity.
Nature cell biology - 1 Aug 2017
Bitler Benjamin G, Wu Shuai, Park Pyoung Hwa, Hai Yang, Aird Katherine M, Wang Yemin, Zhai Yali, Kossenkov Andrew V, Vara-Ailor Ana, Rauscher Frank J, Zou Weiping, Speicher David W, Huntsman David G, Conejo-Garcia Jose R, Cho Kathleen R, Christianson David W, Zhang Rugang
Abstract excerpt
ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be explored. Here, we show that HDAC6 activity is essential in ARID1A-mutated ovarian cancers. Inhibition of HDAC6 activity...
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