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Article

Genetic Associations Between IL-6 and the Development of Autoimmune Arthritis Are Gender-Specific.

Frontiers in immunology - 1 Jan 2021

Hong Jianqiao, Qu Zihao, Ji Xiaoxiao, Li Congsun, Zhang Geng, Jin Ciliang, Wang Jie, Zhang Yongxing, Shen Yue, Meng Jiahong, Zhou Chenhe, Fang Chaohua, Wang Wei, Yan Shigui

Abstract excerpt

Objectives: To find out the genetic association between IL6 and autoimmune arthritis. Methods: We performed a two-sample Mendelian randomization (MR) study using multiple genome-wide association studies (GWAS) datasets. Furthermore, a sex-stratified MR study was performed to identify sexual dimorphism in the association between IL6 and autoimmune arthritis. Then, LocusZoom plots were displayed based on the IL6R...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34539640
DOI: 10.3389/fimmu.2021.707617
PMCID: PMC8447937

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