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Article

Repetitive spikes of glucose and lipid induce senescence-like phenotypes of bone marrow stem cells through H3K27me3 demethylase-mediated epigenetic regulation.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2021

Horitani Keita, Iwasaki Masayoshi, Kishimoto Hiroshi, Wada Kensaku, Nakano Miyuki, Park Haengnam, Adachi Yasushi, Motooka Daisuke, Okuzaki Daisuke, Shiojima Ichiro

Abstract excerpt

Bone marrow-derived endothelial progenitor cells (EPCs) contribute to endothelial repair and angiogenesis. Reduced number of circulating EPCs is associated with future cardiovascular events. We tested whether dysregulated glucose and/or triglyceride (TG) metabolism has an impact on EPC homeostasis. The analysis of metabolic factors associated with circulating EPC number in humans revealed that postprandial...

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PMID: 34533398
DOI: 10.1152/ajpheart.00261.2021

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