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Co-mutations of epidermal growth factor receptor and BRAF in Chinese non-small cell lung cancer patients

1 Aug 2021

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) and BRAF are 2 driver genes in non-small cell lung cancer (NSCLC) which are normally mutually exclusive. It has been previously reported that the existence of BRAF V600E in EGFR-mutated NSCLC patients could cause resistance to EGFR tyrosine kinase inhibitors (TKIs), but the influence of other BRAF actionable mutations on resistance to EGFR-TKIs has not yet been...

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PMID: 34532458
DOI: 10.21037/atm-21-3570

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