Article
Role of inflammation and oxidative stress in tissue damage associated with cystic fibrosis: CAPE as a future therapeutic strategy.
Molecular and cellular biochemistry - 1 Jan 2022
Soares Victor Emanuel Miranda, do Carmo Thiago Inácio Teixeira, Dos Anjos Fernanda, Wruck Jonatha, de Oliveira Maciel Sarah Franco Vieira, Bagatini Margarete Dulce, de Resende E Silva Débora Tavares
Abstract excerpt
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, responsible for the synthesis of the CFTR protein, a chloride channel. The gene has approximately 2000 known mutations and all of them affect in some degree the protein function, which makes the pathophysiological manifestations to be multisystemic, mainly affecting...
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