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Article

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2016

Jelinic Petar, Schlappe Brooke A, Conlon Niamh, Tseng Jill, Olvera Narciso, Dao Fanny, Mueller Jennifer J, Hussein Yaser, Soslow Robert A, Levine Douglas A

Abstract excerpt

Small cell carcinoma of the ovary, hypercalcemic type is an aggressive tumor generally affecting young women with limited treatment options. Mutations in SMARCA4, a catalytic subunit of the SWI/SNF chromatin remodeling complex, have recently been identified in nearly all small cell carcinoma of the ovary, hypercalcemic type cases and represent a signature molecular feature for this disease. Additional biological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26564006
DOI: 10.1038/modpathol.2015.129
PMCID: PMC4697871

Genes

SMARCA2
SMARCA4
POLE
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.PMID 26564006Read ↗

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4.Semantic proximity Read ↗

Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT)Semantic proximity Read ↗

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary.Semantic proximity Read ↗

Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis.Semantic proximity Read ↗

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.Semantic proximity Read ↗

Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic TypeSemantic proximity Read ↗

Biallelic somatic SMARCA4 mutations in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).Semantic proximity Read ↗

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.Semantic proximity Read ↗

An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular FindingsSemantic proximity Read ↗

Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.Semantic proximity Read ↗

No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour.Semantic proximity Read ↗

Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT).Semantic proximity Read ↗

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