Article
Single-nucleotide polymorphism of the osteoprotegerin gene and its association with bone mineral density in Chinese postmenopausal women.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2012
Feng Guixi, Meng Limin, Wang Hui, Lu Yun, Jia Jian, Zhang Yinguang, Zhang Haibin, Zhang Bo
Abstract excerpt
OBJECTIVE: Osteoporosis is a common complex and polygenic disease in postmenopausal women, which is characterized by a decrease in bone mineral density (BMD). The osteoprotegerin (OPG) is an important candidate gene in the pathogenesis of osteoporosis. The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in the OPG gene and BMD. METHODS: OPG gene polymorphisms...
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