Article
Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome.
Parkinsonism & related disorders - 1 Sept 2016
Mishima Takayasu, Ishikawa Taizo, Imamura Keiko, Kondo Takayuki, Koshiba Yasushi, Takahashi Ryosuke, Takahashi Jun, Watanabe Akihiro, Fujii Naoki, Tsuboi Yoshio, Inoue Haruhisa
Abstract excerpt
BACKGROUND: Perry syndrome is a rare autosomal dominant disorder clinically characterized by parkinsonism with depression/apathy, weight loss, and central hypoventilation. Eight mutations in DCTN1 gene have been reported. A novel disease model is required because the detailed pathogenesis remains unclear. METHODS: To develop a novel model, we generated induced pluripotent stem cells (iPSCs) from a Perry syndrome...
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