Article
Inside the pocket: Critical elements of HLA-mediated susceptibility to cervical precancerous lesions.
HLA - 1 Nov 2021
Gonçalves Letícia Boslooper, de França Patrícia Pinho, Petry Natália Angelica, de Souza Xavier Marina Bárbara, de Carvalho Newton Sérgio, Bicalho Maria da Graça, Boldt Angelica Beate Winter, de Araujo-Souza Patrícia Savio
Abstract excerpt
Human papillomavirus (HPV) infection is a necessary cause for cervical cancer (CC), but it also depends on genetic factors, such as HLA polymorphism. However, few reports addressed the role of amino acids residues at the HLA peptide-binding cleft in HPV-related cervical disease. Therefore, we aimed to investigate the association between HLA-B, HLA-C, and HLA-DRB1 polymorphism and amino acid residues composing the...
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