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Article

Apparent mineralocorticoid excess: report of six new cases and extensive personal experience.

Journal of the American Society of Nephrology : JASN - 1 Nov 2006

Morineau Gilles, Sulmont Véronique, Salomon Remi, Fiquet-Kempf Beatrice, Jeunemaître Xavier, Nicod Jérôme, Ferrari Paolo

Abstract excerpt

In mineralocorticoid target tissues such as the cortical collecting duct in the kidney, the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) is responsible for the peripheral inactivation of cortisol to cortisone, thereby protecting the mineralocorticoid receptor from inappropriate activation by cortisol. Mutations in the HSD11B2 gene cause the syndrome of apparent mineralocorticoid excess, an...

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Identifiers

PMID: 17035606
DOI: 10.1681/ASN.2006060570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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