Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In-depth examination of PrPSc in Holstein cattle carrying the E211K somatic mutation of the bovine prion protein gene (PRNP).

Transboundary and emerging diseases - 1 Jul 2022

Kim Yong-Chan, Park Kyung-Je, Hwang Ji-Yong, Park Hoo-Chang, Kang Hae-Eun, Sohn Hyun-Joo, Jeong Byung-Hoon

Abstract excerpt

Prion diseases are transmissible spongiform encephalopathies caused by deleterious prion protein (PrPSc ) derived from normal prion protein (PrPC ), which is encoded by the prion protein gene (PRNP). We performed an in-depth examination to detect PrPSc by using enzyme immunoassay (EIA), real-time quaking-induced conversion reactions (RT-QuIC) and protein misfolding cyclic amplification (PMCA) in nine brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to Cattle Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalopathy, Bovine Spongiform

Share to Mutation

Share to Prion Diseases

Share to Prion Proteins

Share to Prions

Source

Identifiers

PMID: 34470082
DOI: 10.1111/tbed.14309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In-depth examination of PrPSc in Holstein cattle carrying the E211K somatic mutation of the bovine prion protein gene (PRNP).PMID 34470082Read ↗

First Report of the Potential Bovine Spongiform Encephalopathy (BSE)-Related Somatic Mutation E211K of the Prion Protein Gene (PRNP) in Cattle.Semantic proximity Read ↗

Absence of proteinase K-resistant PrP in Korean Holstein cattle carrying potential bovine spongiform encephalopathy-related E211K somatic mutation.Semantic proximity Read ↗

Detection and Discrimination of Classical and Atypical L-Type Bovine Spongiform Encephalopathy by Real-Time Quaking-Induced ConversionSemantic proximity Read ↗

Detection by real-time quaking-induced conversion (RT-QuIC), ELISA, and IHC of chronic wasting disease prion in lymph nodes from Pennsylvania white-tailed deer with specific PRNP genotypes.Semantic proximity Read ↗

Human PrP E219K as a new and promising substrate for RT-QuIC amplification of human prion strains: a first step towards strain discriminationSemantic proximity Read ↗

Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion.Semantic proximity Read ↗

Clinical Use of Improved Diagnostic Testing for Detection of Prion Disease.Semantic proximity Read ↗

Prevalence of the prion protein gene E211K variant in U.S. cattle.Semantic proximity Read ↗

Chronic wasting disease (CWD) prion detection in blood from pre-symptomatic white-tailed deer harboring PRNP polymorphic variants.Semantic proximity Read ↗

Phenotypical Variability in Bovine Spongiform Encephalopathy: Epidemiology, Pathogenesis, and Diagnosis of Classical and Atypical Forms.Semantic proximity Read ↗

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.Semantic proximity Read ↗

Real-time qPCR is a powerful assay to estimate the 171 R/Q alleles at the PrP locus directly in a flock's raw milk: a comparison with the targeted next-generation sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.