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Article

Association of PARK-2 Non-synonyms Polymorphisms and Their In Silico Validation Among North Indian Colorectal Cancer Patients.

Journal of gastrointestinal cancer - 1 Sept 2022

Bhat Zafar Iqbal, Naseem Afreen, Kumar Bhupender, Ponnusamy Kalaiarasan, Tiwari Raj Ranjan, Sharma G D, Rizvi M Moshahid Alam

Abstract excerpt

PURPOSE: PARK2 is a potential tumour suppressor gene and its genetic alterations (regionic loss) are common across many human cancers. The association of PARK2 germline variations (SNPs) with Parkinson's has been shown, but their association in development and progression of cancer remains elusive. The aim of this study was to identify association of PARK2 polymorphisms (rs1801474, rs1801334) with colorectal...

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PMID: 34467515
DOI: 10.1007/s12029-021-00693-z

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